The paper aims to demonstrate the possibility of consistently accepting the existence of effective mental causality in the fundamentally physical world. We suppose that the concept of causality in J. Kim’s exclusion argument against mental causation, which implies а generative conception of causal relations, can be revised taking into account the specificity of the multilevel organization of living objects. Rejection of the mechanistic model of causality as a linear process, allows you to maintain commitment to the principle of causal closure of the physical world and at the same time explain how top-down causality at the macro level is possible. For this, we use the model of a fractal tree of causal chains by J. Lowe, in which mental causality plays the role of an indirect cause of a fact. We carry out a meaningful distinction between the causality of facts and events by resorting to the multilevel model of J. Ellis, in which mental causality can be considered as a macro-level fact that has a selective effect on physical events of lower levels, taking into account a wide environmental context.