This article reveals the idea of the importance in the emerging civilizational transformations of Siberia as a mega-region with a unique multi-level spatial potential - biosphere, geopolitical, economic and cultural. The authors note that in the conditions of a systemic crisis, the study and development of the Siberian space should acquire a qualitatively new level and become a leading project that would ensure the transition to a new development strategy. At the same time, the main priorities are the environmental, economic, scientific and educational and cultural ones, which are designed to replace purely financial, economic, political and technocratic guidelines. Researchers assign a special role in these processes to the problem of the formation of value attitudes of modern youth, called upon to embody in real life the principles of a new spiritual and ecological civilization. The data of a sociological study of the value orientations of Siberian youth in agricultural universities in Siberia are presented.